The NBA playoff opener proved to be the farewell for Rose, who is almost certainly assured of missing the London Olympics as well. The Americans will be trying to defend their 2008 gold medal and Rose would have been a key player.
Rose scored 23 points and added nine rebounds and nine assists in helping the Bulls seize a huge lead late against the 76ers but coach Tom Thibodeau opted to keep Rose in the lopsided game, unhappy at how the Bulls were playing.
"A guy can get hurt any time. You have to deal with it," Thibodeau said. "The score was going the other way. We weren't closing the game out the right way."
In another East opener, the Miami Heat beat New York 100-67 behind 32 points from LeBron James. The visiting Knicks made 27 turnovers and matched their lowest one-game point total in playoff history.
"I was happy I was able to attack," said James, who shot 10-of-14 from the field and 11-of-14 from the free-throw line. "I'm just trying to be in attack mode throughout these games."
Already underdogs, the Knicks also suffered a painful loss as guard Iman Shumpert sustained a torn left knee ligament that will also keep him out the rest of the campaign.
Elsewhere in the East, the Orlando Magic scored the last 11 points en route to an 81-77 victory over the Indiana Pacers at Indianapolis.
The Magic, without three-time Defensive Player of the Year Dwight Howard after his back surgery, nevertheless held the Pacers without a point in the last four minutes of the contest.
But the shocker of the day was the Bulls, whose 50-win season gave them a home-court edge throughout the playoffs, losing Rose, who missed 27 games this season with various injuries.
With 1:20 remaining, Rose planted his feet for a jump shot and his left knee buckled. Rose jumped but passed the ball off to a teammate and used his hands to land carefully, then lowered himself onto the court and rolled onto his back.
Grimacing as he grabbed his knee, Rose lay on the court while being examined by a trainer then was helped up and off the court to the locker room.
Fans briefly chanted "M-V-P" as Rose got up but most were shocked and even teammates were wide-eyed as they watched their top playmaker hobble off.
"At first it's kind of scary for everybody, not just us, the whole city of Chicago," Bulls starter Richard Hamilton said. "My heart kind of dropped."
Hamilton backed Thibodeau's decision to keep Rose on the court in the final minutes.
"In playoff basketball, you never want to give a team confidence," Hamilton said. "If you have a team down, you have to try to keep them down."
Added teammate Taj Gibson: "He wanted to be in the game. We wanted to send a strong message."
Rose, who was 9-of-23 from the field, had missed 12 games this season for a groin injury and five games each for back, toe and ankle problems.
The Bulls went 18-9 without him and 32-7 with him in the lineup and that time with Rose sidelined has allowed the rest of the roster to have faith in those who will take his place now.
Joakim Noah voiced both concern for Rose and determination that his absence won't derail the Bulls' playoff bid.
"I consider Derrick a little brother and to see him hurting is never good," Noah said, then added: "We're a team, you know?
"We play tough basketball, good defense. Regardless of what happens, we're a capable group."
Rose had missed only three games in six years until this season, when the league wedged 66 games into four months after the season was shortened due to a money dispute between club owners and players that was settled last November. (www.rappler.com)